Sensible Medicine

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The Guy in Room 20

Sensible Medicine

On a recent shift, I received sign-out for Room 20, a 46 year old man with a history of schizophrenia as well as alcohol and cannabis abuse. He came to us from a nursing home where he lives. He accidentally set his room on fire with a cigarette, prompting the nursing home to kick him out for being a risk to the facility. Although he had no acute medical issues, he was sent to the emergency department so “the health care system” could find him a new home.

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Diseases Just Learned: Part 2

Sensible Medicine

Following up with another 35 “diseases just learned.” Please look back to last week’s intro if you are just coming to this series. Like Part I, this is a gift to our paid subscribers. This Substack is reader-supported. If you appreciate our work, consider becoming a free or paid subscriber.

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Vinay at FDA; what's next for Sensible Medicine; ask us anything answers

Sensible Medicine

John and Adam discuss our hopes for Vinay’s tenure at the FDA and how we intend to keep Sensible Medicine a vibrant place on Substack, a place where we will continue to showcase a range of ideas and opinions about all things bio-medicine. We also answer some of the questions from our recent “ask us anything” post.

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Two Important Concepts in Medical Practice Emerged from the Comments Yesterday

Sensible Medicine

I enjoyed reading the comments on yesterday's post regarding the positive results of the ESSENCE trial of semaglutide vs placebo in patients with metabolic dysfunction-associated steatohepatitis (MASH). Thank you to those who took the time to write. I wanted to share some very brief thoughts on two basic tenets of medical practice that emerged from the thoughtful commentary.

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Perhaps the Strongest Benefit of GLP1a drugs is.

Sensible Medicine

Three professors, writing in the Lancet , estimated that the global prevalence of the condition is 25%. A modeling study predicted that its prevalence will rise sharply in the coming decade. The condition has a terrible name. It’s called metabolic dysfunction-associated steatohepatitis (MASH). That’s its new name. The old names, non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH) were not much better.

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Caring for Patients, Not Judging Them

Sensible Medicine

One of the many great things about being a general internist is the exposure to the wondrous diversity of humanity. I am a better person for having brief, but intense, visits with some 50 people every week. These people grew up all over the world and have worked in every imaginable field. I see people barely scraping by financially and people with unimaginable wealth.

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How Not to Get Fooled by the Medical Literature - Part 1 - Course Introductio

Sensible Medicine

The most common question we get asked is: is there a course on how to become better at critically reading medical research. Well, now there is! This is the first of 9 videos that we recorded as part of a course on clinical appraisal, and there will be many more to come. We call our class: How Not to Get Fooled by the Medical Literature. These are topics that each of us teaches separately, but, here, for the first time, we teach them together, and the whole is more than the sum of the parts.