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A review of the newly approved novel non-opioid pain reliever suzetrigine (Journavx)

Sensible Medicine

A Google search brings up news releases from Vertex , and news coverage—which are essentially the same and lacking links to the evidence. The differences (from baseline) at each time are summed and weighted to come up the score. Last week the FDA approved a novel non-opioid pain medication. This was much more difficult to find.

Follow-Up 320
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I Am Afraid of Early Cancer Detection

Sensible Medicine

It’s been a few years since I first heard about the Galleri test produced by the Menlo Park startup Grail. Galleri is a blood-based screening test for cancer. For a couple of reasons, I didn’t work very hard to learn about the Galleri test. Second, I was worried that this test might have real promise.

Tests 363
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Friday Reflection 41: Sometimes I Just Need to Complain

Sensible Medicine

What there was -- courtesy of colleagues from across the country – were cases illustrating needless excess, careless follow-up, poor commitment to clinical care, and the devaluation of primary care that undermines our entire system. They also repeated all the tests that the community hospital had done.

Follow-Up 278
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4 Doximity GPT Prompts to Simplify Your Administrative Workload

Doximity

She estimates that this prompt saves her up to two hours per week , and sometimes even more when demand is high. She estimates that this prompt saves her about an hour daily , adding up to 7 hours weekly and nearly 28 hours monthly. Follow-up in three months with repeat labs. GPT helps me generate them efficiently."

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Universal Depression Screening Leads to Unnecessary Harm

Sensible Medicine

The USPSTF claims "screening interventions" decrease the prevalence of depression at six-month follow-up by an odds ratio of 0.60. This number is surprising when we consider the following: A meta-analysis of six RCTs found the benefit of SSRIs, compared to placebo, to be small and statistically insignificant at six months.

Follow-Up 361
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How medical school fails students

Sensible Medicine

The medical college admission test contains many irrelevant questions that have nothing to do with being a doctor. There was a follow-up component to the biochemistry question, and it too was a logic puzzle, however, unfortunately it was incorrect. Next up… residency. I recently did some sample MCAT questions.

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Adam Cifu is Wrong About Masking

Sensible Medicine

In a follow up post , Adam Cifu, my friend and colleague, took me to task. ” Photo via instagram (you can follow me there). Those are the loose, plastic ones that end up in the ocean, strangling turtles and other sea creatures, after being used for armed robberies or college protests. A reduction of 3%.

Follow-Up 359